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4-fa powder 4-Fluoroamphetamine (4-FA; 4-FMP; PAL-303; “Flux“), also known as para-fluoroamphetamine (PFA) is a psychoactive research chemical of the phenethylamine and substituted amphetamine chemical classes. It produces stimulant and entactogenic effects, and is described subjectively as being between amphetamine and MDMA. As a recreational drug, 4-FA is sometimes sold along with related compounds such as 2-fluoroamphetamine and 4-fluoromethamphetamine.

Molecular formula: C9H12FN

Timeline
Oral
Total: 4 – 7 hours (at least somewhat longer for the stimulation vs. entactogen activity)

Onset: 20 – 40 minutes

Usage
4-Fluoroamphetamine
4-FA is popular in the Netherlands where it is predominantly used for its specific effects (77% of users) rather than its legal status (18%). 4-FA has become illegal since May 2017.

Effects
The subjective effects of 4-fluoroamphetamine include euphoria which some find similar to the effects of MDMA and amphetamine, increased energy (stimulation), mood elevation, feelings of warmth and empathy, excessive talking, bruxism, and suppressed appetite (anorexic). The general course of effects involves primarily empathogenic effects for the first few hours, which fades out as increased stimulation develops over the next several hours.

The dopamine reuptake inhibition produced by 4-FA is stronger than that of either 4-CA or 4-IA. 4-FA also produces less hyperthermia than similar compounds such as PMA, 3-MTA and 4-methylamphetamine.4-FA was popular in the Netherlands where it was predominantly used for its specific effects (77% of users) rather than its legal status (18%).4-FA has become illegal since May 2017.Since the ban usage has decreased a lot. Accurate statistics of usage are not available until 2020, but submitted samples to get tested were counted. In 2016 1.100 (10%) of samples tested for DIMS were 4-FA samples, in 2024 less than 50 4-FA samples were submitted. In 2020 0,3% of Dutch adults used 4-FA in the previous year, in 2024 this was just 0,1%.