Flubromazolam

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Flubromazolam is a triazolobenzodiazepine (TBZD), a structural class closely related to other benzodiazepines but with a fused triazole ring. Its chemical name is 8-bromo-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, and it has been catalogued in chemical reference databases such as PubChem. It appears as a white crystalline powder when sold in raw active form. Flubromazolam was first described in the 1970s in pharmaceutical research, but unlike therapeutic benzodiazepines such as diazepam or alprazolam, it was never approved for medical use. Instead, it has emerged in recent decades as a designer benzodiazepine, sold online as a so-called “research chemical.”

Pharmacology and potency

Flubromazolam is a positive allosteric modulator at the GABA_A receptor. Like other benzodiazepine-type compounds, it enhances the effect of the inhibitory neurotransmitter GABA, producing sedative, anxiolytic, hypnotic, muscle relaxant, and anticonvulsant effects.

One of the most notable features of flubromazolam is its extraordinary potency. Case reports and pharmacological studies indicate that doses as low as 0.25–0.5 mg may cause intense sedation, amnesia, and impaired motor coordination. At higher exposures, profound unconsciousness and respiratory depression have been observed, especially when combined with other central nervous system depressants (opioids, alcohol, gabapentinoids).

Its elimination half-life has been reported in the range of 18–36 hours, meaning that sedation can persist well into the next day, contributing to accidental overdosing when redosing occurs before the prior dose has cleared.

Powder form — significance and risks

In regulated pharmaceutical contexts, active pharmaceutical ingredients (APIs) like benzodiazepines are formulated into tablets or capsules with precise dosing controls. Flubromazolam, however, is typically distributed in illicit settings as unformulated powder or dissolved into blotters/liquids for easier handling.

Because active doses are measured in micrograms, powder form carries extreme risk: even tiny measurement errors can multiply the effective dose several times. Contamination, uneven distribution in homemade formulations, and mislabeling as more common benzodiazepines (e.g., alprazolam or diazepam) further heighten the danger.