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Buy 6-APDB Powder, also call (6-(2-Aminopropyl)-2,3-dihydrobenzofuran or (6-APDB, 4-Desoxy-MDA, EMA-3)) is a stimulant and entactogen drug of the phenethylamine and amphetamine classes. It is an analogue of MDA where the heterocyclic 4-position oxygen from the 3,4-methylenedioxy ring has been replaced with a methylene bridge. 5-APDB (3-Desoxy-MDA) is an analogue of 6-APDB where the 3-position oxygen has been replaced with a methylene instead. 6-APDB, along with 5-APDB, was first synthesized by David E. Nichols in the early 1990s while investigating non-neurotoxic MDMA analogues.

In animal studies, 6-APDB fully substitutes for MBDB and MMAI but not for amphetamine or LSD. In vitro, 6-APDB has been shown to inhibit the reuptake of serotonin, dopamine, and norepinephrine with IC50 values of 322 nM, 1,997 nM, and 980 nM, respectively. These values are very similar to those of MDA, but with those for the catecholamines slightly lower in comparison, perhaps more similarly to MDMA. In contrast, 5-APDB is highly selective for serotonin. Though 6-APDB does not substitute for amphetamine in rats at the doses used in referenced study, based on its in vitro profile it can be suggested that it may have amphetamine-like effects at higher doses.

The unsaturated benzofuran derivative 6-APB, or 6-(2-aminopropyl)benzofuran is also known, but the difference in pharmacological effects between 6-APB and 6-APDB is unclear.

6-APDB is a class B drug in the UK since June 10, 2013. It is banned by a blanket law on benzofurans and related compounds.

6-APB is similar in structure to MDA, and is part of the phenethylamine and amphetamine classes. Its pharmacological action is an agonist to the three main serotonin receptors (5-HTP2A/B/C), with effects said to range from euphoria through to increased energy and empathy towards others.

Synonyms

6-(2-Aminopropyl)Benzofuran
Benzo Fury

Technical Information

Formal Name: ?-methyl-6-benzofuranethanamine, monohydrochloride
CAS Number: 286834-84-2
Molecular Formula: C11H13NO • HCl
Formula Weight: 211.7
Purity: ?98%
Formulation: A crystalline solid
?max: 207, 246, 276, 285 nm
SMILES: CC(N)CC1=CC2=C(C=C1)C=CO2.Cl
InChi CodeInChI=1S/C11H13NO.ClH/c1-8(12)6-9-2-3-10-4-5-13-11(10)7-9;/h2-5,7-8H,6,12H2,1H3;1H
InChi Key: APEWOTOLPKNSPE-UHFFFAOYSA-N
Shipping & Storage Information
Storage: -20°C
Shipping: Room Temperature in continental US; may vary elsewhere
Stability: ? 2 years
WARNING This product is not for human or veterinary use.

Formal Name 1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid
CAS Number 1400742-41-7
Synonyms

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Buy 6-MAPB Powder (1-(benzofuran-6-yl)-N-methylpropan-2-amine) is a psychedelic and entactogenic drug which is structurally related to 6-APB and MDMA. It is not known to have been widely sold as a “designer drug” but has been detected in analytical samples taken from individuals hospitalised after using drug combinations that included other benzofuran derivatives. 6-MAPB was banned in the UK in June 2013, along with 9 other related compounds which were thought to produce similar effects.

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Note: The rest of the comments are mostly for tracking the history of identifying the contents of this sample.

Initially, the lab’s GC/MS technique could not differentiate between 6-MAPB and 5-MAPB. The substance was tentatively identified as being either 6-MAPB or 5-MAPB.6-apb powder for sale

Erowid ordered several lab standards for similar substances that the lab used to calibrate their GC/MS equipment to better be able to identify this class of substances. After examining these new chemical standards, the lab changed its identification of this sample 6-APDB.

This identification is still tentative because we have not yet been able to acquire a lab standard for 6-APDB. However, the lab is confident that the sample submitted is NOT an -MAPB or -APB.6-apb buy

Effects
The reported effect is the feeling of energy and euphoria, which are as high as those after the ecstasy consumption. The drug is able to increase music appreciation along with trippy and empathogenic qualities. Along with positive results, people who buy 6-MAPB online also report some adverse ones, namely:

hallucinations;
insomnia;
appetite loss and weight loss;
paranoia (severe stage);
tachycardia;
jaw tension.
Researchers warn most users about possible brain damage as well as neurotoxicity, serotonin syndrome. Other adverse body reactions are closely related to those experienced after the intake of MDA. They are more severe than MDMA results. Besides, 6-MAPB for sale can trigger addiction that is as serious as in case with most amphetamines.

Doses can be light (20-40 mg), regular (40-80 mg) and strong ones (80-100 mg). When the agent is insufflated, the doses must be lower to achieve the same results: light – 10-20 mg, regular – 20-40 mg and strong ones – 40-100 mg. When the drug is consumed orally it starts acting within several minutes and promises effects that last for 5 or 10 hours. The after effects remain for nearly 4 more hours. If the compound is insufflated, it works just the same as in case when taken orally.

Chemical and physical data
Formula: C12H15NO

Molar mass: 189.25 g·mol?1

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What Is BK-EBDP ?

BK-EBDP Powder, also known as N-ethylpentylone, βk-EBDP, or Ephylone, is a synthetic cathinone — a group of stimulant research chemicals chemically similar to compounds found in the khat plant. These substances are often referred to as “designer stimulants” or “bath salts.”
The full chemical name is 1-(benzo[d][1,3]dioxol-5-yl)-2-(ethylamino)pentan-1-one.

BK-EBDP first appeared on the research chemical market in the mid-2010s as a substitute for methylone and pentylone, both of which had been placed under international control. It has been detected in seized powders, tablets, and capsules sold as MDMA, “ecstasy,” or other stimulants.

Chemical Properties and Structure

• IUPAC Name: 1-(1,3-benzodioxol-5-yl)-2-(ethylamino)pentan-1-one

• Chemical Formula: C₁₄H₁₉NO₃

• Molecular Weight: 249.3 g/mol

• Common Names: bk-EBDP, βk-EBDP, Ephylone, N-ethylpentylone

• Chemical Class: Synthetic Cathinone / Phenethylamine Derivative

BK-EBDP is structurally related to pentylone (bk-MBDP) and methylone (bk-MDMA), both of which act as stimulants through enhanced monoamine release (dopamine, norepinephrine, serotonin).

How BK-EBDP Works (Pharmacology)

BK-EBDP acts as a central nervous system stimulant, primarily by increasing the availability of dopamine and norepinephrine in the brain.
Research suggests it functions as:

• A dopamine transporter (DAT) inhibitor

• A norepinephrine transporter (NET) inhibitor

• A weak serotonin transporter (SERT) inhibitor

This pharmacological profile produces wakefulness, alertness, euphoria, and stimulation, but also raises risks of anxiety, hypertension, tachycardia, and paranoia.

Detection and Identification

BK-EBDP can be identified in biological and forensic samples using:

• GC-MS (Gas Chromatography–Mass Spectrometry)

• LC-MS/MS (Liquid Chromatography–Tandem Mass Spectrometry)

• FTIR Spectroscopy

• NMR (Nuclear Magnetic Resonance)

These techniques allow toxicologists to distinguish BK-EBDP from other cathinones and confirm its presence in seized materials or biological fluids.

How BK-EBDP Works 

BK-EBDP acts as a central nervous system stimulant, primarily by increasing the availability of dopamine and norepinephrine in the brain.
Research suggests it functions as:

• A dopamine transporter (DAT) inhibitor

• A norepinephrine transporter (NET) inhibitor

• A weak serotonin transporter (SERT) inhibitor

This pharmacological profile produces wakefulness, alertness, euphoria, and stimulation, but also raises risks of anxiety, hypertension, tachycardia, and paranoia.

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Buy Butylone Crystal online, also known as ?-keto-N-methylbenzodioxolylbutanamine (?k-MBDB), is an entactogen, psychedelic, and stimulant psychoactive drug of the phenethylamine chemical class. It is the ?-keto (substituted cathinone) analogue of MBDB and the substituted methylenedioxyphenethylamine analogue of buphedrone. Butylone was first synthesized by Koeppe, Ludwig, and Zeile in 1967. It remained an obscure product of academia until 2005

Butylone can be synthesized in a laboratory via the following route: 3,4-methylenedioxybutyrophenone dissolved in dichloromethane to bromine gives 3?,4?-methylenedioxy-2-bromobutyrophenone. This product was then dissolved in dichloromethane and added to an aqueous solution of methylamine (40%). HCl was then added. The aqueous layer was removed and made alkaline by using sodium bicarbonate. For the extraction of the amine ether was used. To get butylone a drop of ether and HCl solution was added

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Butylone acts in a similar way as MDMA and Methylone, it causes an increase in extracellular monoamine levels
Butylone was first synthesized by Koeppe, Ludwig and Zeile which is mentioned in their 1967 paper. It remained an obscure product of academia until 2005 when it was sold as a designer drug. Butylone shares the same relationship to MBDB as methylone does to MDMA (“Ecstasy”). Formal research on this chemical was first conducted in 2009, when it was shown to be metabolised in a similar manner to related drugs like methylone
Butylone, also known as ?-keto-N-methylbenzodioxolylbutanamine (?k-MBDB), is an entactogen, psychedelic, and stimulant psychoactive drug of the phenethylamine chemical class. It is the ?-keto (substituted cathinone) analogue of MBDB and the substituted methylenedioxyphenethylamine analogue of buphedrone , Buy Butylone Crystal Alberta ,Research chemicals for sale Canada , Where to order Butylone Online Ottawa , Purchase Empathogens / Entactogens Edmonton

There are three major metabolic pathways of bk-MBDB as shown in the figure. As result of demethylenation followed by O-methylation bk-MBDB metabolises into 4-OH-3-MeO and 3-OH-4-MeO metabolites in human urine. The second pathway is a ?-ketone reduction into ?-ketone reduced metabolites. The third pathway is a N-dealkylation into N-dealkyl metabolites. The first two pathways occur more than pathway three. The most common metabolite is the 4-OH-3-MeO metabolite. The metabolites containing a hydroxyl-group would be excreted as their conjugates in urine.

Contents hide
1. History
2. Chemical and physical data
3. See also
History
Butylone was first synthesized by Koeppe, Ludwig and Zeile which is mentioned in their 1967 paper. It remained an obscure product of academia until 2005 when it was sold as a designer drug. Butylone shares the same relationship to MBDB as methylone does to MDMA (“Ecstasy”). Formal research on this chemical was first conducted in 2009, when it was shown to be metabolised in a similar manner to related drugs like methylone.

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Buy Dibutylone Crystal (bk-DMBDB) is a stimulant drug of the amphetamine, phenethylamine, and cathinone drug classes. It is structurally related to butylone, a designer drug that has been detected in products marketed as bath salts or plant food.

In 2018, dibutylone was the third most common drug of the cathinone class to be identified in Drug Enforcement Administration seizures.

Legal status
In United States, dibutylone is on the list of Schedule I Controlled Substances as a positional isomer of pentylone.

Effects

The effects of Dibutylone will vary depending on your dosage and tolerance, for best results you should take a small “test dose” and monitor any changes after taking the dose. If all is well after the test dose, feel free to up the dosage in order to truly experience the effects of the drug. Some of the commonly reported effects are listed below:

A feeling of wakefulness and increased alertness

Euphoria or dysphoria (this will vary from person to person, but will also depend on the dosage)
Trouble sleeping at a reasonable time
Derealization and hallucinations (this again depends on the individual, but is seen mostly in those who take a large dose or extend use)
Increased blood pressure
Increased body temperature, possibly sweating
Feeling a nauseous
Erectile dysfunction (short term only)

So as you can see, Dibutylone has similar effects to party drugs such as MDMA. Please note however, that the effects you experience will depends greatly on you as an individual and the dosage you took, as always it’s best to start a low dosage and build up so you understand your tolerance of the drug. Also remember that taking the drug orally will results in a longer high but will also take longer to get started; it’s best not to re-dose even if you feel that the drug hasn’t affected you.dibutylone crystal online.

Properties
Chemical formula: C13H17NO3

Molar mass: 235.283 g·mol?1

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

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Buy Dimethylone Crystal also call bk-MDDMA is a potential psychotropic designer drug of the phenethylamine, amphetamine, and cathinone chemical classes. It is structurally related to methylone, a designer drug that has been detected in products marketed as bath salts, plant food, and tablets.

Bk-MDDMA (hydrochloride) is a potential psychotropic designer drug of the phenethylamine, amphetamine, and cathinone chemical classes. It is structurally related to methylone, a designer drug that has been detected in products marketed as bath salts, plant food, and tablets.1,2 This product is intended for forensic purpose.

bk-MDDMA (hydrochloride) is also a potential psychoactive mind-altering drug of the phenethylamine, amphetamine, and cathinone chemical categories. It’s structurally associated with methylone, a psychoactive drug that has been detected in product marketed as bath salts, plant food, and tablets. Dimethylone is meant for forensic functions.Buy Dimethylone Online

Formal Name 1-(1,3-benzodioxol-5-yl)-2-(dimethylamino)-1-propanone, monohydrochloride

CAS Number: 109367-07-9

Synonyms: Dimethylone

Molecular Formula: C12H15NO3 • HCl

Formula Weight 257.7

Purity ?98%

Formulation: A crystalline solid

?max: 235, 282, 320 nm

SMILES CC(N(C)C)C(C1=CC(OCO2)=C2C=C1)=O.Cl

InChI Code InChI=1S/C12H15NO3.ClH/c1-8(13(2)3)12(14)9-4-5-10-11(6-9)16-7-15-10;/h4-6,8H,7H2,1-3H3;1H

InChI Key RTMQTJLQSAOBKY-UHFFFAOYSA-N

Storage: -20°C.

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3,4-methylenedioxy-N,N-Dimethlyone crystal

or alternatively N,N-dimethyl-3,4-methylenedioxycathinone or n-methyl-methylone

Dimethylone is a research chemical which has significantly gained in popularity lately. The product is often sold as MDMA or bk-MDMA as well.The effects are however not the same, as Dimethylone belongs to the cathinone, amphetamine, and phenethylamine chemical classes. Dimethylone is colorless on its own but takes the appearance of a white powder after being crushed. Dimethylone has a stimulating effect similar to cocaine, although this transitions to the effect of amphetamine after 1 – 2 hours.

Dimethylone bk-MDDMA (hydrochloride) is a potential psychotropic designer drug of the phenethylamine, amphetamine, and cathinone chemical classes. It is structurally related to methylone, a designer drug that has been detected in products marketed as bath salts, plant food, and tablets.1,2 This product is intended for forensic purposes.

Dimethylone bk-MDDMA (hydrochloride) is a potential psychotropic designer drug of the phenethylamine, amphetamine, and cathinone chemical classes. It is structurally related to methylone, a designer drug that has been detected in products marketed as bath salts, plant food, and tablets.1,2 This product is intended for forensic purposes.

Dimethylone bk-MDDMA (hydrochloride) is a potential psychotropic designer drug of the phenethylamine, amphetamine, and cathinone chemical classes. It is structurally related to methylone, a designer drug that has been detected in products marketed as bath salts, plant food, and tablets.1,2 This product is intended for forensic purposes.

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Buy Ethylone Crystal, also known as 3,4-methylenedioxy-N-ethylcathinone (MDEC, ?k-MDEA), is a recreational designer drug classified as an entactogen, stimulant, and psychedelic of the phenethylamine, amphetamine, and cathinone chemical classes. It is the ?-keto analogue of MDEA (“Eve”). Ethylone has only a short history of human use and is reported to be less potent than its relative methylone. In the United States, it began to be found in cathinone products in late 2011.

Very little data exists about the pharmacological properties, metabolism, and toxicity of ethylone, and although several ethylone-related deaths have been reported, but the cause of death was not due to ingestion of ethylone.

Description
The compound is administered in different ways. The two main ones are orally and intranasally. When administered orally, the substance is more effective, which is possible thanks to high 5HT serotonin receptors concentration. Some of the positive effects after you buy Ethylone online include color enhancements and boundaries softening, increased appreciation for music and people, who surround you, stimulation and euphoria, a few entactogenic and empathy effects. While these are positive influences, here are some negative ones: depression and severe paranoia, hypertension in people with heart problems and diseases, anxiety and nausea in rare cases.

When it is taken orally, Ethylone for sale starts acting within half an hour after administration. First feelings are stimulation and euphoria. Others occur, depending on the dosage. The peak of effects is reached in an hour or more. The effects resemble those of MDMA, yet they aren’t as potent as the latter ones. This peak may hold on for about 3 or 5 hours. The duration will depend on the dosage and tolerance to the chemicals. People, who follow a healthy diet routine, don’t suffer from severe health effects.

Buy Ethylone for approved purposes, if you don’t want to suffer from any complications. It isn’t intended for human and animal administration, yet for researches, trials and laboratory testing only.

Chemical and physical data

Formula: C12H15NO3

Molar mass: 221.2524 g/mol g·mol?1

Pharmacokinetics

Analysis of human and rat urine for the metabolites of bk-amphetamines suggested that ethylone was degraded in the following metabolic steps:

N-deethylation to the primary amine.
Reduction of the keto moiety to the respective alcohol.
Legal Status
As of October 2015 Ethylone is a controlled substance in China.

See also
5-Methylethylone

Methylone is the substituted cathinone analog of MDMA and the 3,4-methylenedioxy analog of methcathinone. The only structural difference of methylone with respect to MDMA is the substitution of 2 hydrogen atoms by 1 oxygen atom in the ? position of the phenethylamine core, forming a ketone group.

Methylone was first synthesized by the chemists Peyton Jacob III and Alexander Shulgin in 1996 for potential use as an antidepressant. Methylone has been sold for recreational use, taking advantage of the absence of legal prohibition of this compound in many countries.

Resemblance to MDMA
Structural similarities between some amphetamine-like stimulants and their 3,4-methylenedioxy- derivatives.
Left: amphetamine, methamphetamine and methcathinone.
Right: MDA, MDMA, and methylone
Methylone substitutes for MDMA in rats trained to discriminate MDMA from saline. Methylone does not substitute for amphetamine or for the hallucinogenic DOM in animals trained to discriminate between these drugs and saline. Further, also in common with MDMA, methylone acts on monoaminergic systems. In vitro, methylone has one third the potency of MDMA at inhibiting platelet serotonin accumulation and about the same in its inhibiting effects on the dopamine and noradrenaline transporters.

In spite of these behavioral and pharmacological similarities between methylone and MDMA, the observed subjective effects of both drugs are not completely identical. Alexander Shulgin wrote of the former.

Pharmacology
Methylone acts as a mixed reuptake inhibitor/releasing agent of serotonin, norepinephrine, and dopamine. In comparison to MDMA, it has approximately 3x lower affinity for the serotonin transporter, while its affinity for the norepinephrine and dopamine transporters is similar. Notably, methylone’s affinity for the vesicular monoamine transporter 2 (VMAT2) is about 13x lower than that of MDMA. The results of these differences in pharmacology relative to MDMA are that methylone is less potent in terms of dose, has more balanced catecholaminergic effects relative to serotonergic, and behaves more like a reuptake inhibitor like methylphenidate than a releaser like amphetamine; however, methylone has relatively robust releasing capabilities, perhaps due to its ability to phosphorylate the monoamine transporters being similar in potency relative to MDMA.

Pharmacokinetics
The two major metabolic pathways in mammals for methylone are N–demethylation to methylenedioxycathinone (MDC), and demethylation followed by O–methylation of the 3- or 4-hydroxy group to 4-hydroxy-3-methoxymethcathinone (HMMC) or 3-hydroxy-4-methoxymethcathinone (3-OH-4-MeO-MC). When 5 mg/kg of methylone was administered to rats, it was found that around 26% was excreted as HMMC within the first 48 hours (less than 3% excreted unchanged).

Commercial distribution
Bottles of Explosion
Analysis of “Explosion” has confirmed that the active ingredient is methylone. Many other formulations marketed as household chemicals, as well as the pure powder, have been sold.

Etymology
“Methylone” is also a trademarked brand name for an injectable form of methylprednisolone, a corticosteroid hormone used to treat arthritis and severe allergic reactions; hence, methylone may be confused with it. Aside from context, they can be distinguished by the fact that the name will usually be capitalized when referring to the prescription drug.

A proposed alternate name is ?k-MDMA, or beta-keto-MDMA. While this nomenclature has not caught on because the name “methylone” became widely used before the conflicting Methylone trademark was noticed, the analogous names for related chemicals ?k-MDEA and ?k-MBDB have become the established names for those substances.

Chemical and physical data:

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Dibutylone, also commonly referred to as bk-DMBDB, Buy Dibutylone Crystals Online, is a stimulant drug of the amphetamine, phenethylamine, and cathinone drug classes. These types of drugs feature a phenethylamine core with an alkyl group attached to the alpha carbon, and a ketone group attached to the beta carbon. Cathinone occurs naturally in the plant khat, the leaves of which are often chewed as a recreational drug. Looking to buy Dibutylone Crystals Online? You are in the right place.

Dibutylone is a potentially psychotropic designer drug. It is structurally related to methylone, a designer drug that has been detected in products like bath salts, plant food, and tablets. However, the effects of a chemical substance such as this are still unknown in regards to organic specimens, including human subjects. It is considered to be a biochemical with widespread applications in Mass Spectrometry. Therefore, those looking to buy Dibutylone might intend to use it in research areas like Neuroscience and Forensic Science.

Research Chemical  For Sale

Some more technical information on this chemical substance includes:

Formal Name: 1-(1,3-benzodioxol-5-yl)-2-(dimethylamino)-1-butanone, monohydrochloride

Formula Weight: 271.7

Purity: Greater than or equal to 98%

Formulation: A crystalline solid

Storage: -20°C

Stability: Typically no less than two years worth of stability

While the effects of this type of chemical substance on human subjects is widely unknown, many have started to buy Dibutylone for use as a recreational designer drug. Drugs of this type are typically purchased with the hopes of achieving euphoric experiences, both physically and cognitively. Many seek alternatives like this in comparison to more commonly obtained prescription drugs or over the counter medications in the hopes of achieving a stronger experience. Some also seek these alternatives attempting to find a drug that offers these experiences with fewer of the negative side effects that other common drugs might yield.

In comparison to other drugs like this, many users find that the experience is mild at best, only resulting in a slight euphoric experience. Only a very small number of users have cited this, however, with the others mostly citing no change in mental state whatsoever. Some did note a pleasant rush, more openness when it comes to sharing emotions and thoughts, and a positive lift in mood. These users have cited ingesting nasally to be the best experience, however they have also ingested the chemical substance orally by mixing with water and drinking the resultant substance.

Drugs like this typically yield certain negative side effects as well, including occasional nausea and even hallucinations. Some common side effects users of Dibutylone have cited include feelings of a heavy chest, an increase in heart rate, and constipation. Many compare it to other MDMA chemical substances, except they claim this substance has more controllable effects in comparison to others.

All products, including the substance Dibutylone, are sold as research specimens exclusively and are not for human consumption under any circumstances. Due to the lack of research on organic specimens, including human subjects, the effects are widely unpredictable and it should only be used as a research chemical.

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Methylone is the substituted cathinone analog of MDMA and the 3,4-methylenedioxy analog of methcathinone. The only structural difference of methylone with respect to MDMA is the substitution of 2 hydrogen atoms by 1 oxygen atom in the ? position of the phenethylamine core, forming a ketone group.

Methylone was first synthesized by the chemists Peyton Jacob III and Alexander Shulgin in 1996 for potential use as an antidepressant. Methylone has been sold for recreational use, taking advantage of the absence of legal prohibition of this compound in many countries.

Resemblance to MDMA
Structural similarities between some amphetamine-like stimulants and their 3,4-methylenedioxy- derivatives.
Left: amphetamine, methamphetamine and methcathinone.
Right: MDA, MDMA, and methylone
Methylone substitutes for MDMA in rats trained to discriminate MDMA from saline. Methylone does not substitute for amphetamine or for the hallucinogenic DOM in animals trained to discriminate between these drugs and saline. Further, also in common with MDMA, methylone acts on monoaminergic systems. In vitro, methylone has one third the potency of MDMA at inhibiting platelet serotonin accumulation and about the same in its inhibiting effects on the dopamine and noradrenaline transporters.

In spite of these behavioral and pharmacological similarities between methylone and MDMA, the observed subjective effects of both drugs are not completely identical. Alexander Shulgin wrote of the former.

Pharmacology
Methylone acts as a mixed reuptake inhibitor/releasing agent of serotonin, norepinephrine, and dopamine. In comparison to MDMA, it has approximately 3x lower affinity for the serotonin transporter, while its affinity for the norepinephrine and dopamine transporters is similar. Notably, methylone’s affinity for the vesicular monoamine transporter 2 (VMAT2) is about 13x lower than that of MDMA. The results of these differences in pharmacology relative to MDMA are that methylone is less potent in terms of dose, has more balanced catecholaminergic effects relative to serotonergic, and behaves more like a reuptake inhibitor like methylphenidate than a releaser like amphetamine; however, methylone has relatively robust releasing capabilities, perhaps due to its ability to phosphorylate the monoamine transporters being similar in potency relative to MDMA.

Pharmacokinetics
The two major metabolic pathways in mammals for methylone are N–demethylation to methylenedioxycathinone (MDC), and demethylation followed by O–methylation of the 3- or 4-hydroxy group to 4-hydroxy-3-methoxymethcathinone (HMMC) or 3-hydroxy-4-methoxymethcathinone (3-OH-4-MeO-MC). When 5 mg/kg of methylone was administered to rats, it was found that around 26% was excreted as HMMC within the first 48 hours (less than 3% excreted unchanged).

Commercial distribution
Bottles of Explosion
Analysis of “Explosion” has confirmed that the active ingredient is methylone. Many other formulations marketed as household chemicals, as well as the pure powder, have been sold.

Etymology
“Methylone” is also a trademarked brand name for an injectable form of methylprednisolone, a corticosteroid hormone used to treat arthritis and severe allergic reactions; hence, methylone may be confused with it. Aside from context, they can be distinguished by the fact that the name will usually be capitalized when referring to the prescription drug.

A proposed alternate name is ?k-MDMA, or beta-keto-MDMA. While this nomenclature has not caught on because the name “methylone” became widely used before the conflicting Methylone trademark was noticed, the analogous names for related chemicals ?k-MDEA and ?k-MBDB have become the established names for those substances.

Chemical and physical data:
Formula: C11H13NO3