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Buy 5FN-PB22 Powder (5F-QUPIC or quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate) is a designer drug which acts as a cannabinoid agonist. The structure of 5F-PB-22 appears to have been designed with an understanding of structure–activity relationships within the indole class of cannabinoids.

Pharmacology
5F-PB-22 acts as a full agonist with a binding affinity of 0.468 nM at CB1 and 0.633 nM at CB2 cannabinoid receptors.

Legal status
As of October 2015 5F-PB-22 is a controlled substance in China.

In January 2014, 5F-PB-22 was designated as a Schedule I controlled substance in the United States after several deaths were associated with its use.

In the United Kingdom, 5F-PB-22 is now classified and controlled as a Class B drug, following the November 2016 amendment to the Misuse of Drugs Act 1971. Several other synthetic cannabinoids structurally related to JWH-018, like 5F-PB-22, were also classified in this amendment.

Chemical and physical data
Formula: C23H21FN2O2

Molar mass: 376.431 g·mol?1

Purity ?98%
Formulation A neat solid
SMILES O=C(OC1=C(N=CC=C2)C2=CC=C1)C3=CN(CCCCCF)C4=C3C=CC=C4
InChI Code InChI=1S/C23H21FN2O2/c24-13-4-1-5-15-26-16-19(18-10-2-3-11-20(18)26)23(27)28-21-12-6-8-17-9-7-14-25-22(17)21/h2-3,6-12,14,16H,1,4-5,13,15H2
InChI Key

MBOCMBFDYVSGLJ-UHFFFAOYSA-N

Technical Information
Formal Name 1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid
CAS Number 1400742-41-7
Synonyms

5-fluoro QUPIC

See also
AM-2201
JWH-018
QUCHIC
QUPIC
SDB-001
SDB-005

Chemical and Structural Characteristics

The structure of 5F-NPB-22 includes a fluorinated side chain, indicated by the “5F” prefix. Fluorination is a common modification in medicinal chemistry, as it can affect a compound’s potency, metabolic stability, and interaction with biological targets.

Key aspects of its chemical profile include:

• Affinity for CB1 and CB2 receptors
• Lipophilic properties that influence absorption and distribution
• Structural similarity to other indole-based synthetic cannabinoids
• Sensitivity to environmental factors such as heat and light 5F-NPB-22 (5FN-PB22) is a synthetic cannabinoid that plays an important role in modern scientific and forensic research. Its study provides valuable insights into receptor interactions, chemical design, and the identification of emerging substances within the NPS category.