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Chemical and Structural Characteristics

Furanylfentanyl shares the core structure of fentanyl, including:

• A piperidine ring
• An anilide group
• A phenethyl backbone

What distinguishes furanylfentanyl is the presence of a furan ring substitution, which alters its chemical behavior. Structural modifications like this can significantly affect:

• Receptor binding affinity
• Lipid solubility (ability to cross the blood-brain barrier)
• Duration of action
• Metabolic breakdown pathways

Even minor changes in fentanyl analogs can result in major differences in potency, making them particularly important to monitor in toxicology.

This product is intended for forensic and research applications.

Side effects
Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening.

Life-threatening adverse reactions caused by furanylfentanyl use have been observed in Sweden and Canada. At least seven deaths in Cook County, Illinois, have been linked to furanylfentanyl in 2016, with additional deaths in suburban Chicago in 2017.

Detection in biological fluids
Furanylfentanyl may be measured in blood or urine to monitor for abuse, confirm a diagnosis of poisoning, or assist in a medicolegal death investigation. Commercially available immunoassays are often used as initial screening tests, but chromatographic techniques are generally used for confirmation and quantitation. Blood furanylfentanyl concentrations are expected to be in a range of 1-45 ?g/L in victims of fatal overdosage.

Synonyms
Fu-F
2-Furanyl fentanyl
Technical Information
Formal Name: N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-2-furancarboxamide, monohydrochloride
CAS Number: 101365-56-4
Molecular Formula: C24H26N2O2 • HCl
Formula Weight: 410.9
Purity: ?98%
Formulation: A neat solid
SMILES: O=C(C1=CC=CO1)N(C2CCN(CCC3=CC=CC=C3)CC2)C4=CC=CC=C4.Cl
InChi CodeInChI=1S/C24H26N2O2.ClH/c27-24(23-12-7-19-28-23)26(21-10-5-2-6-11-21)22-14-17-25(18-15-22)16-13-20-8-3-1-4-9-20;/h1-12,19,22H,13-18H2;1H
InChi Key: MKKAYRKIIKMNAP-UHFFFAOYSA-N
DEA Schedule: I
Shipping & Storage Information
Storage: -20°C
Shipping: Room Temperature in continental US; may vary elsewhere
Stability: See Certificate of Analysis
See also
3-Methylbutyrfentanyl
3-Methylfentanyl
4-Fluorofentanyl
?-Methylfentanyl
Acetylfentanyl
Acrylfentanyl
Benzoylfentanyl
Butyrfentanyl
List of fentanyl analogues
Mirfentanil